Targacept to Report Fourth Quarter and 2013 Financial Results on February 13, 2014

Targacept, Inc. (NASDAQ: TRGT), a clinical-stage biopharmaceutical company developing novel NNR Therapeutics™, today announced it will report financial results for the fourth quarter and year ended December 31, 2013 on Thursday, February 13, 2014, before the U.S. financial markets open.

Management will discuss the fourth quarter and year-end financial results, provide a business and program update and discuss expectations for the future via conference call at 8:30 a.m. Eastern Time on Thursday, February 13, 2014. The conference call may be accessed by dialing 866.515.2911 for domestic participants and 617.399.5125 for international participants (reference passcode 72076219). A replay of the conference call may be accessed beginning approximately two hours following the call on February 13, 2014 through February 27, 2014 by dialing 888.286.8010 for domestic callers and 617.801.6888 for international callers (reference passcode 60502052).

A live audio webcast of the conference call will be accessible from the Investor Relations page of Targacept’s website, www.targacept.com. To ensure a timely connection to the webcast, it is recommended that users register at least 15 minutes prior to the scheduled start time. An archived version of the webcast will also be available for replay on the Investor Calendar section of the Investor Relations page of Targacept’s website for at least two weeks following the call.

About Targacept

Targacept is developing an advanced clinical pipeline of NNR Therapeutics™ to treat patients suffering from serious nervous system and gastrointestinal/genitourinary diseases and disorders. Many diseases arise from abnormalities in signaling within and between the brain and other organ systems such as the bladder and the GI tract. Targacept’s NNR Therapeutics™ have the potential to normalize these signaling pathways to provide significant medical benefit. Targacept is dedicated to building health and restoring independence for patients. For more information, please visit www.targacept.com.

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